Abstract. This research aimed to produce anti-claudin18.2 (CLDN 18.2)/anti-PD-L1 bispecific antibodies to enhance the therapeutic index and expand the responsive population of the parent anti-CLDN ...

Abstract. The BCR-ABL1–negative myeloproliferative neoplasms (e.g., essential thrombocythemia, polycythemia vera, and primary myelofibrosis) are a group of heterogeneous hematologic malignancies that ...

Translational Relevance We report that by covalently combining the CEACAM5-targeting humanized antibody, labetuzumab, with the active drug form of the cancer prodrug, CPT-11, therapy of human colonic ...

Abstract. Purpose: The high affinity receptor 1 (NTSR1) and its agonist, neurotensin (NTS), are correlated with tumor cell aggressiveness in most solid tumors. As chemoresistance and tumor ...

Remarkable progress made against cancer in the United States is reflected by a 33% decline in the overall cancer mortality rate between 1991 and 2020 (1). Despite this reduction, 2,001,140 new cases ...

Systematic multiomic analysis has revealed ancestry-dependent molecular alterations, but their impact on the efficacy of anticancer treatment is yet largely unknown. In this study, we analyzed ...

2019 Meetings Abstracts: AACR Special Conference on Modernizing Population Sciences in the Digital Age February 19–22, 2019; San Diego, CA Proceedings: AACR Annual Meeting 2019 March 29–April 3, 2019; ...

Activation of sonic hedgehog (Shh) signaling has been implicated in progression of a variety of tumors. In this study, we elucidated a role for Shh in the invasion of gastric tumors and determined the ...

In May 2009, a summary of the latest assessment of the carcinogenicity of metals, arsenic, dusts, and fibers, including asbestos, by the International Agency for Research on Cancer (IARC) Monograph ...

When determining the prognosis of a patient with a chronic disease, for example, a specific type of cancer, this quantity is usually expressed in terms of an overall survival (OS) probability. The ...