The first episode of Your Friendly Neighborhood Spider-Man takes a drastic detour from the MCU in pretty significant ways.

The character was originally supposed to be played by Tom Holland back when it was a tie-in for Marvel’s MCU Spider-Man movies, but the project eventually transformed into something separate. Your Friendly Neighborhood Spider-Man ’s first trailer showed Norman Osborn mentoring Peter Parker instead of Iron Man,

Spider-Man's latest animated outing has arrived on Disney +. Recap everything that happened in this new corner of the MCU

The premiere episode of Marvel's animated Spider-Man show pinballs between being an MCU cover band and doing its own thing.

Man’s placement in the endless web known as the Marvel Cinematic Universe, executive producer Dana Vasquez-Eberhardt said something happens in the new Disney+ show that branches it off from the traditional timeline Tom Holland’s Spider-Man occupies.

In the MCU, Peter Parker's billionaire mentor was Iron Man. But in Your Friendly Neighborhood Spider-Man, Peter's mentor is not as friendly.