Matthew Stafford and the Rams look to bolster their NFC West title hopes with a win over the San Francisco 49ers at Levi's Stadium on Thursday night.

The Los Angeles Rams and San Francisco 49ers will lead Week 15 off with a huge game that will have major playoff implications for the NFC West and wild-card race. The Rams (7-6) will head up the Pacific Coast on a high after last week's wild 44-42 win over the Buffalo Bills.

Experts point to Detroit’s dynamic offense and a Bills defense that has struggled recently as key reasons for the Lions’ edge heading into the Week 15 clash in Motown. The Lions are also returning to a more typical schedule following a grueling stretch of games and are expected to have several key players back in the lineup.

When the two Super Bowl contenders match up at the Lions' home field on Sunday afternoon, the primary concern for the Bills will be getting their defense straightened out. Buffalo had its seven-game winning streak snapped by the Rams last week,