It’s Week 13 in the NFL, and the Buffalo Bills are preparing to host the San Francisco 49ers on Sunday Night Football at 8:20 p.m. Buffalo (9-2) enters the contest having won six straight and is coming off a bye week. Meanwhile, San Francisco (5-6) has dropped two straight and three of five as injuries continue to pile up.

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

Bills' QB Josh Allen is the current favorite for MVP. Expectations aren't something I like to make a habit. However, it's hard not to expect the best from Allen and the Bills this week. Beating the Chiefs the way they did helped them check off that confidence box, and they did it on their 12th straight week of football.

The Buffalo Bills may have something extra to be thankful for on Thursday. Buffalo could be a win away from a fifth straight title in the AFC East shortly after the Thanksgiving feast. The Bills can clinch the division in Week 13 if the Miami Dolphins lose to the Green Bay Packers at Lambeau Field on Thursday Night Football and Buffalo defeats the San Francisco 49ers at Highmark Stadium on Sunday Night Football.