Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

The San Francisco 49ers are reeling and now head to Buffalo for a prime time game. Will they have their starting QB back in ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Three teams face playoff-clinching scenarios in Week 13. Here's what the Bills, Lions and Chiefs need to earn a playoff berth ...

Former Buffalo Bills (and current San Francisco 49ers) defender Leonard Floyd will be facing off against his old club this ...

Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

ATS on my picks in Week 12. However, the good news is that I went 3-2 ATS on my locks of the week, which claws us back over ...

There is a High Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the San Francisco 49ers ...

There is a high Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the 49ers (5-6) and the ...

NFL Week 13 picks, predictions for Bears vs Lions, Chargers vs Falcons, Steelers vs Bengals, Cardinals vs Vikings, Eagles vs ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

Former NFL offensive lineman Kyle Long recently compared Buffalo Bills quarterback Josh Allen to NBA superstar LeBron James.