Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

The Bills are off to their best start since 1993, and could punch their ticket to the 2024 playoffs as early as this week.

Weather looks set to play a role in the Buffalo Bills' Week 13 matchup with the San Francisco 49ers.

The Buffalo Bills will have to wait and see what happens with tight end Dalton Kincaid as his status for this week is up in ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

The Bills have allowed the seventh fewest points. They lead the NFL with the fewest explosive pass plays of 20-plus yards ...

Milano practiced without a red non-contact jersey for the first time since his bicep injury in August and was listed on the ...

Simpson carried the ball 29 times against the Lions and set a new NFL record with 273 rushing yards, breaking his own record ...

Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

The Buffalo Bills are set to have a classic snow game matchup against the San Francisco 49ers in Orchard Park.