Christian McCaffrey rarely has been taken off the field since returning from an eight-game absence due to bilateral Achilles ...

They have a tough game in Buffalo on Sunday night. A loss would further complicate their path to the postseason.So how is ...

"We're just going to keep chopping wood," said running back Christian McCaffrey, as more 49ers stars grapple with ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

Deebo Samuel probably is the most disappointing player on the most disappointing team in the NFL through 12 weeks. Here's ...

Bad news for the 49ers. Brock Purdy still isn't ready to resume throwing. Technically, he threw one pass on Wednesday -- a ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

There seems to be a clear point in the season when 49ers linebacker Fred Warner dropped off from being a strong contender for ...

Through the first four weeks of the season, Fred Warner was the front-runner to win the Defensive Player of the Year Award.

The San Francisco 49ers have opened the practice window for linebacker Dre Greenlaw from the Reserve/Physically Unable to ...

San Francisco 49ers defensive end Nick Bosa missed Wednesday's practice as the team began preparations for Sunday's game ...

The early portion of Wednesday's practice produced no encouraging signs for 49ers quarterback Brock Purdy. Brandon Allen, ...