The physiologic roles of E3 ubiquitin ligases have been examined in knockout or mutant mouse models. In previous work with a mouse model that contained a loss of function mutation in the ITCH E3 ...

During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other proteins. This tagging, in turn, helps determine the fate of the targeted ...

Jiangsu Vcare Pharmatech Co. Ltd. has disclosed proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently linked to estrogen receptor (ER) ...

During ubiquitination, a group of enzymes called E3 ubiquitin ligases attach a small protein called ubiquitin to other proteins. This tagging, in turn, helps determine the fate of the targeted ...

TRAF6 is a non-conventional E3 ubiquitin ligase with a unique receptor binding specificity. This protein comprises an N-terminal RING domain, multiple zinc finger motifs, and a C-terminal TRAF domain.

In this webinar, brought to you by Bio-Techne, Jennifer Johnston will discuss how her research of ubiquitin-proteasome system elements, including Parkin E3 ligase, is used to diagnose and treat ...

E3 ligase KO using CRISPR-Cas9 and degradation with dTAG in selected AML, MM and solid cancer cell line. The results will be confirmed by WB and HiBit (dTAG). Determination of the effects of E3 ligase ...

In the body, the glue molecule first binds to a type of enzyme called an E3 ubiquitin ligase, altering the shape of the ligase’s surface so it can then bind to the target protein.

Plants are constantly under siege by pathogens, and their survival depends on precise internal defense strategies. A new ...

During ubiquitination, a small protein known as ubiquitin is attached to other proteins by a class of enzymes known as E3 ...

Apple E3 ligase MdPUB23 mediates ubiquitin-dependent degradation of MdABI5 to delay ABA-triggered leaf senescence. Article Publication Date. 30-Jan-2024. COI Statement.