While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert. If they get back the right players, the Bills will be facing a much tougher game against a playoff-level team desperate to keep their hopes alive.

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game

Bills' QB Josh Allen is the current favorite for MVP. Expectations aren't something I like to make a habit. However, it's hard not to expect the best from Allen and the Bills this week. Beating the Chiefs the way they did helped them check off that confidence box, and they did it on their 12th straight week of football.